Merkel cell polyomavirus and non‐Merkel cell carcinomas: guilty or circumstantial evidence?
نویسندگان
چکیده
منابع مشابه
Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus.
A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen. Previous studies have consistently reported that MCPyV can be detected in approximately 80% of all MCC tumors. We sought to increas...
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Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine carcinoma. Recently, a new polyoma virus has been identified that is clonally integrated in the genome of the majority of MCCs, with truncating mutations in the viral large T antigen gene. We examined the presence of Merkel cell polyomavirus (MCV) in a set of 17 frozen tumor samples by quantitative polymerase chain r...
متن کاملMerkel cell polyomavirus and cutaneous Merkel cell carcinoma
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine skin cancer of elderly patients. Generally, it originates from Merkel cells of the basal layer of the epidermis characterized by typical neuroendocrine granules (neuron-specific enolase; NSE+) and keratin filament (cytokeratin-20; CK20). Its incidence has been increasing in the last two decades, likely because of improved ability t...
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of the fi rst diagnosed case (in Spain) in a human with aseptic meningitis.lence of West Nile virus neutralizing an-tibodies in colonial aquatic birds in southern Spain. and performance testing of quantitative real time PCR assays for infl uenza A and B viral load measurement. Detection and differentiation of pathoge-nicity of avian paramyxovirus serotype 1 from fi eld cases using one-step reve...
متن کاملLack of integrin β5 in Merkel cell carcinomas and derived cell lines is frequently associated with Merkel cell polyomavirus positivity.
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin neoplasia. The merkel cell polyomavirus (MCPyV), a double-stranded DNA tumor virus was discovered in 2008. It is found in approximately 80% of human MCC and is suspected to play a role in MCC development [1]. Both, small tumor and the aminoterminal moiety of the large tumor antigen, were found to be expressed in MCPyV-posi...
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ژورنال
عنوان ژورنال: APMIS
سال: 2020
ISSN: 0903-4641,1600-0463
DOI: 10.1111/apm.13019